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标题: 最大规模大脑研究找出导致大脑老化的因素 [打印本页]

作者: 龙血树 时间: 2018-9-5 21:42
标题: 最大规模大脑研究找出导致大脑老化的因素
本帖最后由龙血树于 2018-9-5 21:51 编辑

Largest brain study of 62,454 scans identifies drivers of brain aging
Schizophrenia, cannabis use, and alcohol abuse are just several disorders that are related to accelerated brain aging
Date:
August 21, 2018
Source:
IOS Press
Summary:
In the largest known brain imaging study, scientists evaluated 62,454 brain SPECT (single photon emission computed tomography) scans of more than 30,000 individuals from 9 months old to 105 years of age to investigate factors that accelerate brain aging.
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In the largest known brain imaging study, scientists from Amen Clinics (Costa Mesa, CA), Google, John's Hopkins University, University of California, Los Angeles and the University of California, San Francisco evaluated 62,454 brain SPECT (single photon emission computed tomography) scans of more than 30,000 individuals from 9 months old to 105 years of age to investigate factors that accelerate brain aging. SPECT tomography) evaluates regional cerebral blood flow in the brain that is reduced in various disorders.

Lead author, psychiatrist Daniel G. Amen, MD, founder of Amen Clinics, commented, "Based on one of the largest brain imaging studies ever done, we can now track common disorders and behaviors that prematurely age the brain. Better treatment of these disorders can slow or even halt the process of brain aging. The cannabis abuse finding was especially important, as our culture is starting to see marijuana as an innocuous substance. This study should give us pause about it."

The current study used brain SPECT imaging to determine aging trajectories in the brain and which common brain disorders predict abnormally accelerated aging. It examined these functional neuroimaging scans from a large multi-site psychiatric clinic from patients who had many different psychiatric disorders, including bipolar disorder, schizophrenia and attention deficit hyperactivity disorder (ADHD).

Researchers studied 128 brain regions to predict the chronological age of the patient. Older age predicted from the scan compared to the actual chronological age was interpreted as accelerated aging. The study found that a number of brain disorders and behaviors predicted accelerated aging, especially schizophrenia, which showed an average of 4 years of premature aging, cannabis abuse (2.8 years of accelerated aging), bipolar disorder (1.6 years accelerated aging), ADHD (1.4 years accelerated aging) and alcohol abuse (0.6 years accelerated aging). Interestingly, the researchers did not observe accelerated aging in depression and aging, which they hypothesize may be due to different types of brain patterns for these disorders.

Commenting on the study, George Perry, PhD, Chief Scientist at the Brain Health Consortium from the University of Texas at San Antonio, said, "This is one of the first population-based imaging studies, and these large studies are essential to answer how to maintain brain structure and function during aging. The effect of modifiable and non-modifiable factors of brain aging will further guide advice to maintain cognitive function."

Co-investigator Sachit Egan, Google Inc. (Mountain View, CA), said, "This paper represents an important step forward in our understanding of how the brain operates throughout the lifespan. The results indicate that we can predict an individual's age based on patterns of cerebral blood flow. Additionally, groundwork has been laid to further explore how common psychiatric disorders can influence healthy patterns of cerebral blood flow."

Story Source:

Materials provided by IOS Press. Note: Content may be edited for style and length.

Journal Reference:

Daniel G. Amen, Sachit Egan, Somayeh Meysami, Cyrus A. Raji, Noble George. Patterns of Regional Cerebral Blood Flow as a Function of Age Throughout the Lifespan. Journal of Alzheimer's Disease, 2018; 1 DOI: 10.3233/JAD-180598

作者: 龙血树 时间: 2018-9-5 21:56
大概结果是：精神分裂症大脑提前四年老化，使用大麻提前2.8年, 躁郁症1.6年，多动症1.4 年，酗酒0.6 年。

作者: 宝贝小猪 时间: 2018-9-6 22:56

龙血树发表于 2018-9-5 08:56
大概结果是：精神分裂症大脑提前四年老化，使用大麻提前2.8年, 躁郁症1.6年，多动症1.4 年，酗酒0.6 年 ...

后果都不是很严重啊。

作者: 龙血树 时间: 2018-9-7 14:15

宝贝小猪发表于 2018-9-6 22:56
后果都不是很严重啊。

这是几年的大脑寿命啊！壕

作者: 易水 时间: 2018-9-10 16:49
本帖最后由易水于 2018-9-10 16:51 编辑

宝贝小猪发表于 2018-9-6 22:56
后果都不是很严重啊。

失去理智和自理能力，完全变成另外一个人，拖累孩子 2~4年，让她在孩子和父亲之间疲于奔命。而这本来是可以含饴弄孙，乐享天年的时间。不严重？

作者: lorry 时间: 2018-9-10 17:58
和合成毒品一样，怀疑电子游戏和色情也是人体承受不了的刺激，对大脑不好。

作者: 常挨揍 时间: 2018-9-10 20:53

龙血树发表于 2018-9-5 21:56
大概结果是：精神分裂症大脑提前四年老化，使用大麻提前2.8年, 躁郁症1.6年，多动症1.4 年，酗酒0.6 年 ...

酗酒0.6年

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